Wednesday, May 20, 2009

Link Between Sedentary Behavior and Uterine Cancer

Women, put down the remote or romance novel and get to exercising! It seems that not only could a little exercise help to reduce weight and other weight-attributing side effects, it may even help to ward off endometrine cancer, also known as uterine cancer, in obese or overweight women. Uterine cancer is the fourth most common cancer in women behind breast cancer, lung cancer and colon cancer.

More than 35,000 women are diagnosed annually in the U.S. with endometrine cancer, the #1 form of gynecologic cancer. The most common subtype is endometrioid adenocarcinoma that usually occurs a few decades after menopause and has been linked to excessive estrogen levels. The most common sign of endometrine cancer is vaginal bleeding between menstrual cycles or after menopause, and the most common treatment is the total removal of the uterus through a surgical procedure known as a hysterectomy.

The American Cancer Society’s Prospective Cancer Prevention Study II Nutrition Cohort found that overweight and obese women, who exercised even lightly or moderately instead of being sedentary, in their spare time, reduced their risks of developing uterine cancer. The study began in 1992 with a questionnaire being mailed to those baseline cohort member’s between 50 and 74 years old, who were chosen for the study and resided in one of the 21 states, with a population based state cancer registries. Detailed information in regards to diet, updated lifestyle factors, and prospective cancer and mortality incidence checks were gathered.

From 1992 to 2001, Dr. Alpha Patel and colleagues with the American Cancer Society gathered research from the participants through completed biannual questionnaires. The questionnaires asked questions in regards to time spent participating in recreational or non-recreational physical activities and questions about their time sitting, not including sitting time at work. They followed nearly 60,000 post menopausal women, according to the American Journal of Epidemiology’s April 15th issue. 314 cases of uterine cancer were reported. The study resulted in the conclusion that women who sat more than three hours a day, not accounting for time sitting at work, increasing their odds of developing uterine cancer by 55 percent.

Get to walking or take part in some form of physical activity, not only to reduce weight and the possible side effects extra weight may cause, but also to ward off cancer. The authors involved in the Prospective Cancer Prevention Study II Nutrition Cohort, released in the most recent issue of the International Journal of Cancer, say that the association between sedimentary behavior and uterine or endometrine cancer may be better defined with discoveries of other studies and that "sedentary behavior has been associated with obesity and with metabolic abnormalities, resulting in increased circulating estrogen, insulin, and other hormones that may promote cell proliferation."

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